Receptors for Human Luteinizing Hormone in Human Corpora Luteal Tissue*

Abstract

Receptors, specific for hLH, were found in human luteal tissue. Binding of ¹²⁵I-hLH was a time-dependent, saturable process that could be competitively inhibited by unlabeled human LH. The dissociate constant of the receptor-LH interaction, using human luteal tissue, was found to be 1.1 × 10⁻⁹M, which is in reasonable agreement with the dissociation constant found using rat luteal tissue. The concentration of LH binding site showed considerable variability among corpora lutea obtained from ten different subjects.