The Complete Nucleotide Sequence of Coxsackievirus B4 and Its Comparison to Other Members of the Picornaviridae
- 1 July 1987
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 68 (7), 1835-1848
- https://doi.org/10.1099/0022-1317-68-7-1835
Abstract
The genome of the prototype strain of coxsackievirus B4 (J.V.B. Benschoten) has been cloned in Escherichia coli and its complete nucleotide sequence determined. Excluding the poly(A) tract, the RNA genome is 7395 nucleotides in length and appears to encode a single polyprotein of 2183 amino acids. The predicted amino acid sequence of the polyprotein shows close homology (88%) to that of the previously sequenced coxsackievirus B3 and to certain regions of the polyproteins of the polioviruses and human rhinovirus 14. This allows identification of putative polyprotein cleavage signals, antigenic domains and other structural features likely to be important to the biological integrity of the virus.This publication has 6 references indexed in Scilit:
- Replicase gene of coxsackievirus B3Journal of Virology, 1984
- Molecular cloning of the genomes of poliovirus type 3 strains by the cDNA: RNA hybrid methodArchiv für die gesamte Virusforschung, 1984
- Membrane fractions active in poliovirus RNA replication contain VPg precursor polypeptidesVirology, 1983
- Primary structure, gene organization and polypeptide expression of poliovirus RNANature, 1981
- Stable hairpin structure within the 5'-terminal 85 nucleotides of poliovirus RNAJournal of Virology, 1981
- Sequence of picornavirus RNAs containing a radioiodinated 5'-linked peptide reveals a conserved 5' sequence.Proceedings of the National Academy of Sciences, 1980