EFFECT OF PH ON THE BINDING OF THEOPHYLLINE TO SERUM-PROTEINS
- 1 January 1979
- journal article
- research article
- Published by Elsevier
- Vol. 120 (1), 83-86
- https://doi.org/10.1164/arrd.1979.120.1.83
Abstract
The binding of the bronchodilator, theophylline, to serum protein within the pH range of 7.0-7.8 was determined by equilibrium dialysis using serum from 8 healthy adult volunteers. The percentage of theophylline bound was independent of the total concentration of the drug but was directly related to pH. Changes in the free fraction of theophylline may alter the therapeutic response, toxic effects and pharmacokinetics; any future studies of the pharmacology of theophylline should assess the acid-base status of the patients and measure free and total theophylline concentrations.This publication has 9 references indexed in Scilit:
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