Inhibition of T-Cell Rosette Formation by Hodgkin-Disease Serum

Abstract

After more than a decade of investigation of lymphoid subpopulations through the use of cell markers, some recent studies are beginning to provide insights into the mysterious process known as Hodgkin's disease. Several different groups working in the field have found conflicting results, reporting either normal or reduced proportions of thymus-dependent (T) cells, usually determined by the ability of these lymphocytes to form rosettes with sheep erythrocytes.¹ In 1974, Bobrove, Fuks, Strober and Kaplan reported that although the proportion of T cells in their patients was normal when measured with a specific anti-T-cell antiserum, many such cells failed to form . . .