Effects of histamine agonists and antagonists on luminol-dependent chemiluminescence of granulocytes
- 1 October 1984
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 15 (3-4), 182-188
- https://doi.org/10.1007/bf01972347
Abstract
Histamine inhibited luminol-dependent chemiluminescence (CL) of granulocytes in a dose-dependent manner, with an ID50 of about 3×10−5 M. Dimaprit, a selective H2-agonist, produced a histamine-like effect. Furthermore, cimetidine, ranitidine, and TZU 0460, which are selective H2-antagonists, but not mepyramine, a selective H1-antagonist, blocked the inhibitory effect of histamine on CL. Thus it may be concluded that the inhibitory effect of histamine is mediated via histamine H2-receptors. H1- and H2-antagonistsper se, except at extremely high concentrations, had no effect on CL of granulocytes.This publication has 32 references indexed in Scilit:
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