Some Considerations of Radiation-induced Cell Transformationin Vitro

Abstract

Experimental data concerning the influence of the cell density on the induction rate of cell transformations in C3H mouse embryo cell lines (10T1/2) after X-irradiation have been reanalysed. The mathematical analysis showed that the transformation frequency can be expressed as the product of two functions, one of which is dependent on radiation dose alone, and the other of which is dependent on the number of cell division cycles alone, in that the probability of the expression of malignant transformation is constant per cellular mitosis. Therefore the transformation frequency measured for different experimental conditions can be normalized and consequently compared; one example of data reduction after irradiation of .alpha.-particles is demonstrated.