Fmoc-Peptide Acid Chlorides in Fragment Coupling: Synthesis of β-Casomorphin by 3+2 Divergent Approach

Abstract

Fmoc-peptide acid chlorides are prepared and used as rapid and efficient coupling agents in fragment coupling. Thus the synthesis of the model tetrapeptide Leu-Ala-Gly-Val and P-casomorhin (Tyr-Pro-Phe-Pro-Gly) are accomplished by the (2+2) and (3+2) divergent approach respectively.