INHERITED THYROXINE EXCESS: A SERUM ABNORMALITY DUE TO AN INCREASED AFFINITY FOR MODIFIED ALBUMIN
- 1 October 1981
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 15 (4), 363-371
- https://doi.org/10.1111/j.1365-2265.1981.tb00676.x
Abstract
Further analysis of sera from euthyroid subjects with dominantly-inherited, elevated serum total thyroxine (T4) and free T4 index but with normal free T4 levels was performed as an extension of a previous study. Scatchard analysis and isoelectric focusing of whole sera and purified serum fractions suggest that this T4 excess is due to increased T4 binding by modified serum albumin. Recognition of this syndrome and appreciation that the free T4 index does not reflect the free T4 levels are important to protect patients from the consequences of an incorrect diagnosis of thyrotoxicosis.This publication has 17 references indexed in Scilit:
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