THE ACTION OF THE SYNTHETIC POLYPEPTIDE VALYL-OXYTOCIN ON THE HUMAN UTERUS IN VITRO AND IN VIVO
- 1 November 1959
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. XXXII (III), 391-398
- https://doi.org/10.1530/acta.0.xxxii0391
Abstract
The uterotonic activity of valyl-oxytocin was compared with that of synthetic oxytocin (Syntocinon) unit per unit in vitro and in vivo in 3-point matching assays in 30 women. The contractions of strips of human uterine muscle obtained by cesarean section were studied in vitro, and in vivo uterine motility was recorded with a guard-ring tacodynamometer a few hours postpartum. Valyl-oxytocin was 1.5 times more powerful than synthetic oxytocin in vitro, but 4.5 times more powerful in vivo.Keywords
This publication has 2 references indexed in Scilit:
- SOME PHARMACOLOGICAL ACTIONS OF FOUR SYNTHETIC ANALOGUES OF OXYTOCINBritish Journal of Pharmacology and Chemotherapy, 1957
- *UBER DIE WIRKUNG HYDRIERTER MUTTERKORNALKALOIDE AUF ISOLIERTE MUSKELSTREIFEN DES MENSCHLICHEN UTERUS NAHE AM TERMIN, AM TERMIN UND WAHREND DER GEBURT1954