Increased Activity of Renal Glutaminases in Guinea Pig Following Prolonged Administration of Acid or Alkali.

Abstract

Increased activity of the enzymes involved in ammonia metabolism in the kidneys of guinea pigs was produced by prolonged treatment with acid or alkali. When the results were expressed on a per cell basis, glutaminase I was increased in acidosis, while in alkalosis glutaminases I and II and the glutamine-synthesizing enzyme were increased. These increases in activity are suggestive of enzyme induction though all the criteria for this process have not yet been fulfilled.