Cytolethal distending toxin (CLDT) production by enteropathogenic Eschrichia coli (EPEC)

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Abstract
Culture supernates of 16 strains of EPEC belonging to 6 different serogroups, when assayed on Chinese Hamster Ovary (CHO) cells up to 96–120 h, induced distinct morphological changes. The supernate activities were heat-labile, unrelated to heat-labile enterotoxin (LT), verotoxin (VT), or hemolysin, did not show necrosis in rabbit skin and caused no fluid secretion in the rabbit ileal loop assay (RILA). Simulatneous production of CLDT and heat-stable enterotoxin (ST) were detected in four EPEC strains.