Following a study of the exocrine pancreas based on duodenal intubation in 32 cases of hemochromatosis (22 untreated and 10 treated), the principal findings are as follows: normal absence of noteworthy disturbance of lipase secretion after CCK; in the untreated group, by comparison with the control subjects and with alcoholic cirrhosis, considerable increase in the volume of duodenal juice collected after secretin, with low concentration but high flow of bicarbonates; absence of hypersecretion in the treated group whose secretory pattern tends to become identical to that of the control subjects.