Two translocations of chromosome 15q associated with dyslexia
Open Access
- 1 October 2000
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 37 (10), 771-775
- https://doi.org/10.1136/jmg.37.10.771
Abstract
Developmental dyslexia is characterised by difficulties in learning to read. As reading is a complex cognitive process, multiple genes are expected to contribute to the pathogenesis of dyslexia. The genetics of dyslexia has been a target of molecular studies during recent years, but so far no genes have been identified. However, a locus for dyslexia on chromosome 15q21 (DYX1) has been established in previous linkage studies. We have identified two families with balanced translocations involving the 15q21-q22 region. In one family, the translocation segregates with specific dyslexia in three family members. In the other family, the translocation is associated with dyslexia in one family member. We have performed fluorescence in situ hybridisation (FISH) studies to refine the position of the putative dyslexia locus further. Our results indicate that both translocation breakpoints on 15q map within an interval of approximately 6-8 Mb between markers D15S143 and D15S1029, further supporting the presence of a locus for specific dyslexia on 15q21.Keywords
This publication has 14 references indexed in Scilit:
- Family-based association mapping provides evidence for a gene for reading disability on chromosome 15q.Human Molecular Genetics, 2000
- A new gene (DYX3) for dyslexia is located on chromosome 2.1999
- Susceptibility loci for distinct components of developmental dyslexia on chromosomes 6 and 15.1997
- The genetics of cornea plana congenita.Journal of Medical Genetics, 1996
- A YAC contig map of the human genomePublished by Cold Spring Harbor Laboratory ,1995
- Quantitative Trait Locus for Reading Disability on Chromosome 6Science, 1994
- Cosegregation of balanced translocation (1;2) with retarded speech development and dyslexiaThe Lancet, 1993
- Suggestive linkage of developmental dyslexia to chromosome 1p34-p36The Lancet, 1993
- Evidence for a genetic aetiology in reading disability of twinsNature, 1987
- Specific Reading Disability: Identification of an Inherited Form Through Linkage AnalysisScience, 1983