Some Hormonal Effects on Phosphorylation in the Liver of Rats.

Abstract

There appears to be a constant relationship of the synthesis of phospholipides to that of nucleoproteins whether or not the liver is fatty, fibrosed or normal. This constant rate of synthesis of liver phospholipides appears changed very little by dietary intake, but may be influenced by metabolic requirements of the body. In view of these findings, expts. were undertaken to ascertain the effects of various hormones on phospholipide and nucleoprotein synthesis in the liver. Male, albino rats (100-110 g.) were divided into 3 groups, with a control for each group maintained on a 25% casein diet. The phospholipide and nucleoprotein synthesis was measured with the aid of radioactive P. Thiourea diminished phospholipide and nucleoprotein synthesis in the liver. The fat mobilization fraction of the pituitary gave a 51% increase in total lipides in the liver of rats in 6 hrs. However, there was no change in the synthesis of phospholipides, but a statistical increase in the synthesis of nucleoproteins. The growth hormone increased both nucleoprotein and phospholipide synthesis in the liver of rats.