Nephrotoxicity in Combined Cephalothin and Gentamicin Therapy

Abstract

Thirty-two series of treatment with cephalothin and gentamicin for 5-10 days were administered to 26 patients. An increase in serum creatinine occurred in 6 series. Important factors for the renal damage were elevated pretreatment serum creatinine, elevated serum gentamicin and probably a high serum cephalothin. In 2 patients the nephrotoxicity was fully reversible; the others died before a decisive improvement in renal function could be expected. In 11 of 28 treatment series there was a transient drop in serum K. Since the combination of cephalothin and gentamicin as the primary treatment of life-threatening infection has often proved effective, and since short-lasting treatment seems to entail only a minute risk of nephrotoxicity in patients with normal pretreatment serum creatinine, this treatment in such cases is still preferred.