Polymeric Nanoparticle-Based Activatable Near-Infrared Nanosensor for Protease Determination In Vivo
- 20 October 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in Nano Letters
- Vol. 9 (12), 4412-4416
- https://doi.org/10.1021/nl902709m
Abstract
We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy.Keywords
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