Retro-translocation of proteins from the endoplasmic reticulum into the cytosol
Top Cited Papers
- 1 April 2002
- journal article
- review article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 3 (4), 246-255
- https://doi.org/10.1038/nrm780
Abstract
Proteins that are misfolded in the endoplasmic reticulum are transported back into the cytosol for destruction by the proteasome. This retro-translocation pathway has been co-opted by certain viruses, and by plant and bacterial toxins. The mechanism of retro-translocation is still mysterious, but several aspects of this process are now being unravelled.Keywords
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