STUDIES ON NON‐H‐2 LINKED LYMPHOCYTE ACTIVATING DETERMINANTS I. DESCRIPTION OF THE CELL TYPE BEARING THE MLS PRODUCT
- 1 June 1977
- journal article
- Published by Wiley in International Journal of Immunogenetics
- Vol. 4 (3), 201-213
- https://doi.org/10.1111/j.1744-313x.1977.tb00902.x
Abstract
The non-H-2 linked, lymphocyte activating determinants (LADs), which are coded by the minor (histocompatibility) lymphocyte stimulating locus (Mls), were detected on B lymphocytes, but not on immunoglobulin (Ig) negative or on theta positive T lymphocytes. These determinants, like the complement receptor and surface IgD, develop late in neonatal life. Thus, the Mls coded LADs mark a population of B lymphocytes which are not present in the spleens of newborn to 2-week-old mice. Studies of B lymphocytes derived from the spleens of adult mice indicated that the cells that bear the Mls coded LADs have a high density of surface Ig and possess the complement receptor.Keywords
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