The Sensitivity of Acyclovir-Resistant Mutants of Herpes Simplex Virus to Other Antiviral Drugs
- 1 February 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 143 (2), 281-285
- https://doi.org/10.1093/infdis/143.2.281
Abstract
Three acyclovir (ACV)-resistant mutants derived from a strain of herpes simplex virus (HSV) type 1 were studied to determine the range of their resistance to nine drugs active against HSV. Two of the mutants were thymidine kinase-deficient (TK-) and were resistant to drugs that are usually phosphorylated by HSV TK. The other mutant induced normal levels of TK; it was of special interest since TK+ viruses appear more likely to multiply well in vivo. This mutant was inhibited by “TK-mediated” drugs: idoxuridine, which is already in use, and two drugs with promising clinical potential, 1-β-arabinofuranosylthymine and E-5-(2-bromovinyl)-2′-deoxyuridine. All of the mutants were sensitive to trifluorothymidine and 9-β-D-arabinofuranosyladenine. These results suggest that the study of cross-resistance of HSV strains in vitro will aid in the investigation of alternative drugs for use in effective chemotherapy.Keywords
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