Prostate cancer. Primary hormonal treatment
- 1 February 1993
- Vol. 71 (S3), 1050-1058
- https://doi.org/10.1002/1097-0142(19930201)71:3+<1050::aid-cncr2820711425>3.0.co;2-#
Abstract
No other treatment matches the 40-60% objective response and up to 80% subjective responses for primary hormonal therapy in patients with symptomatic disease. This makes primary hormonal treatment first-line therapy metastatic prostate cancer. The treatment outcome is determined by the initial and intermittent prognostic factors. In the multihormonal environment, several endocrine treatments have shown competing levels of response. Maximal androgen blockade has emerged as the best treatment to achieve a response and even has increased survival modestly. Monotherapy with nonsteroidal antiandrogens plays a role in patients trying to preserve their potency. Pilot treatment adjusted to the medical needs and social preferences of the patient is appropriate and allows a tailored approach to the individual patient.Keywords
This publication has 34 references indexed in Scilit:
- A Comparison of the Morphological Features of Cancer Arising in the Transition Zone and in the Peripheral Zone of the ProstateJournal of Urology, 1991
- The biological significance of low testosterone levels and of adrenal androgens in transplantable prostate cancer linesUrological Research, 1991
- The Endocrinological Basis for Hormonal Therapy of Prostate TumoursPublished by Springer Nature ,1991
- Cancer in the European community and its member statesEuropean Journal of Cancer and Clinical Oncology, 1990
- Prostatic Specific Antigen and the Prediction of Prognosis in Metastatic Prostatic CancerCancer, 1990
- Early Detection of Prostate CancerUrologic Clinics of North America, 1989
- Multivariate Analysis of Prognostic Factors in Patients with Advanced Prostatic Cancer: Results from 2 European Organization for Research on Treatment of Cancer TrialsJournal of Urology, 1989
- The Endocrinology and Developmental Biology of the Prostate*Endocrine Reviews, 1987
- Response criteria for the prostate of the USA national prostatic cancer projectThe Prostate, 1980
- STEROIDS OF ADRENAL ORIGIN METABOLIZED BY HUMAN PROSTATIC TISSUE BOTH IN VIVO AND IN VITROJournal of Endocrinology, 1974