Antiepileptic Drug Monitoring by Chromatographic Methods and Immunotechniques—Comparison of Analytical Performance, Practicability, and Economy

Abstract
Liquid chromatography, gas chromatography, enzyme multiplied immunotechnique, substrate-labeled fluorescence immunoassay and radio immunoassay were applied simultaneously to the routine analysis of a number of patient serums containing phenytoin, phenobarbital, primidone, carbamazepine, ethosuximide, carbamazepine-epoxide, phenylmethylmalondiamide and N-desmethylmethsuximide [antiepileptic drugs].