ACUTE EFFECTS OF TRIETHYL TIN ON THE RAT MYELIN SHEATH
- 12 May 1977
- journal article
- research article
- Published by Wiley in Neuropathology and Applied Neurobiology
- Vol. 3 (3), 169-181
- https://doi.org/10.1111/j.1365-2990.1977.tb00581.x
Abstract
Acute effects of triethyl tin on the rat myelin sheathTriethyl tin, when given intravenously to the rat, produces intramyelin vacuoles in 2 h after 10 mg/kg and 1 h after 20 mg/kg. No preceding changes occur in astro‐cytes, oligodendrocytes, or extracellular space. The vacuoles appear to begin in the outer lamellae of the sheath and may move with time inwards towards the axon. They occupy only a sector of the sheath, at least during the first few hours. Fibres of all sizes are equally affected. It is suggested that this substance acts directly on the membrane of the oligodendroglial myelin. No effects were found on retinal rod cells or peripheral myelin.This publication has 24 references indexed in Scilit:
- Triethyltin Sulfate-Induced Neuropathy in RatsArchives of Neurology, 1976
- THE BINDING OF TRIETHYLTIN TO RAT BRAIN MYELINJournal of Neurochemistry, 1975
- Increase in cerebral fluid in rats after treatment with triethyltinBiochemical Pharmacology, 1975
- Observations on oligodendrocyte degeneration, the resolution of status spongiosus and remyelination in cuprizone intoxication in miceJournal of Neurocytology, 1972
- Ultrastructural changes in isoniazid-induced brain oedema in the dogJournal of Neurocytology, 1972
- Adjustment of the myelin sheath to changes in axon caliberThe Anatomical Record, 1972
- Analysis of the process of sheath expansion in swollen nerve fibersBrain Research, 1970
- Ultrastructural Changes in the Edematous Central Nervous SystemArchives of Neurology, 1965
- Morphological and chemical studies in cerebral edema: Triethyl tin-induced edemaJournal of the Neurological Sciences, 1965
- Further Observations on Triethyltin EdemaArchives of Neurology, 1963