A group of pictures is submitted which seem to indicate without much doubt a distinctly hereditary tendency toward an absence of pigmentation in localized areas of the scalp and skin. Figure 1, a photograph made several years before this report, shows the absence of pigmentation in the hair of the father and a suggestion of vitiligo on the forehead. Unfortunately no further photographic studies can be made of the father, because he is dead. The mother of the children stated, however, that he had vitiliginous areas on the body. Figure 2 shows D. E. W., aged 5, one of the children, and figure 3, M. J. W., aged 4, the other child. The location of the canities was the same in the father as in the daughters, and the vitiliginous areas on the bodies of the children correspond rather closely. The hereditary tendency of this anomaly of pigmentation has frequently