ACCELERATION OF THE BARIUM MEAL THROUGH THE SMALL INTESTINE BY THE C-TERMINAL OCTAPEPTIDE OF CHOLECYSTOKININ

Abstract

During the intravenous infusion of the synthetic C-terminal octapeptide of cholecystokinin (C8-CCK), the barium meal passed from the distal portion of the duodenum to the cecum within 20 minutes in 10 healthy subjects. A contrast medium coating was left on the mucosal surface of almost the whole small intestine. This technique permits the examination of the small bowel in an uninterrupted sequence under fluoroscopy with spot roentgenography of areas of interest. No harmful side effects were encountered. Without C8-CCK, the corresponding transit times in the same subjects were 30-240 minutes.