Early intracellular events in the replication of T4 phage DNA. I. Complex formation of replicative DNA.
- 1 July 1965
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 54 (1), 273-278
- https://doi.org/10.1073/pnas.54.1.273
Abstract
Upon injection parental DNA enters a proteinaceous complex in which the replicative moiety of DNA is preferentially located. This complex can be disrupted by sonication or treatment with proteolytic enzymes. With parental phage of good viability, all the injected DNA undergoes semiconservative replication. The complex formation occurs in the presence of CM. The DNA of UV-inactivated phage is also complexed upon injection. Complex formation as a prerequisite for replication and possibly recombination is emphaslzed.This publication has 5 references indexed in Scilit:
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- REPLICATIVE FRAGMENTATION IN T4 PHAGE: INHIBITION BY CHLORAMPHENICOLProceedings of the National Academy of Sciences, 1963
- Fragmentary transfer of P32-labeled parental DNA to progeny phageVirology, 1963
- The kinetics of parental deoxyribonucleic acid replication, deoxyguanylate kinase formation and 32P-inactivation of the parental virus in Escherichia coli infected with bacteriophage T4Journal of Molecular Biology, 1961
- Fragmentary transfer of P32-labeled parental DNA to progeny phageVirology, 1961