Reversal of Ergotoxine Inhibition of Deciduoma by M.E.D. of Progesterone in Spayed Pseudopregnant Rats

Abstract

Experiments were carried out to ascertain whether the action of ergotoxine ethanesulfonate in disturbing the development of artificially induced decidual response was a target organ competition or a direct antagonism between the ergotoxine which inhibited deciduoma and progesterone which when given simultaneously with the ergot drugs, reversed the inhibition. Minimum effective dose of progesterone for deciduoma formation in spayed pseudopregnant rats was effective in reversing the ergot alkaloid inhibition, even when 12 times the effective dose of ergotoxine was used. Progesterone did not protect rats against ergot toxi-city. The studies indicate the site of action to be at a higher level.