Negative and positive regulation of human leukocyte antigen class I gene transcription in K562 leukemia cells.
Open Access
- 1 December 1987
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 7 (12), 4572-4575
- https://doi.org/10.1128/mcb.7.12.4572
Abstract
The mechanism of transcriptional activation of human leukocyte antigen class I genes by gamma interferon and 5-azacytidine was studied in K562 human leukemia cells. Nuclear run-on transcription assays with various protein and RNA synthesis inhibitors yield evidence for both stimulation of a positive regulatory factor and inhibition of an mRNA that codes for a labile repressor. A novel mechanism is proposed to explain how 5-azacytidine can activate repressed genes without affecting DNA methylation.This publication has 36 references indexed in Scilit:
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