Brief Report: Observations on Conjugated and Unconjugated Blood Folate Levels in Megaloblastic Anemia and the Effects of Vitamin B12

Abstract

Vitamin B₁₂ deficiency was associated with a rise in unconjugated folates and marked depletion of intracellular conjugated folates. The changes could be reversed by giving vitamin B₁₂. These results probably indicate a way by which vitamin B₁₂ and folic acid are interrelated at the cellular level.