Novel Jojoba Oil-Based Emulsion Gel Formulations for Clotrimazole Delivery
- 12 January 2011
- journal article
- Published by Springer Nature in AAPS PharmSciTech
- Vol. 12 (1), 239-247
- https://doi.org/10.1208/s12249-011-9583-4
Abstract
Jojoba oil-based emulgel formulations were prepared using different concentrations of various gelling agents, such as hydroxypropyl methylcellulose (HPMC) and Carbopol 934 P and combination of both. The prepared emulgels were physically evaluated for their stability after temperature cycle test, centrifugation and long-term shelf storage for 1 year at room temperature. The in vitro release at 37°C was studied to define the effect of the concentration and type of the gelling agent. A comparison between the formulated emulgels and two commercially available products, Candistan® and Canesten® creams, was carried out to judge their efficacy and stability. The prepared emulgels exhibited non-Newtonian shear thinning behavior with little or no thixotropy. Four emulgels showed excellent stability as they demonstrated consistent rheological model under different treatment conditions. The in vitro release test showed variation in the extent of percent drug released. The drug release from the commercial preparation was lower than some of the prepared emulgel formulae. One formula containing combination of the two gelling agents (HPMC and Carbopol 934 P), showed excellent stability and high extent of clotrimazole release was microbiologically evaluated against Candida albicans using cylinder and plate method. The selected formula showed superior antimycotic activity compared to the commercially available formulation. Further in vivo animal studies for the obtained stable formula is recommended.Keywords
This publication has 25 references indexed in Scilit:
- Anti-inflammatory effects of jojoba liquid wax in experimental modelsPharmacological Research, 2005
- Rheology and stability of water-in-oil-in-water multiple emulsions containing Span 83 and Tween 80AAPS PharmSci, 2003
- Stability and rheology of emulsions containing sodium caseinate: combined effects of ionic calcium and non-ionic surfactantFood Hydrocolloids, 2003
- Polymer-Stabilized Emulsion Systems: Structural Characteristics and Physical Stability EvaluationDrug Development and Industrial Pharmacy, 2003
- Systematic study of the flow behaviour and mechanical properties of Carbopol® Ultrez™ 10 hydroalcoholic gelsEuropean Journal of Pharmaceutics and Biopharmaceutics, 2002
- Effects of shear on pure and mixed gels of gelatin and particulate whey proteinFood Hydrocolloids, 1998
- Determination of (Pseudo)plastic Flow Properties of Pharmaceutical Semisolids Using Rheological AUC ParametersPharmaceutical Development and Technology, 1997
- A New Physical Model for the Diffusion of Solvents and Solute Probes in Polymer SolutionsMacromolecules, 1996
- Evaluation of Tack Behaviour of Coating SolutionsDrug Development and Industrial Pharmacy, 1990
- The effects of corticosteroids on the reduction of α-adrenoceptor blockade produced by β-adrenoceptor blocking agentsJournal of Pharmacy and Pharmacology, 1972