Chondrogenesis in Tissue Cultures of Muscle Under the Influence of a Diffusible Component of Bone Matrix
- 1 April 1977
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 154 (4), 568-572
- https://doi.org/10.3181/00379727-154-39720
Abstract
Summary Under the influence of a diffusible molecule in bone matrix gelatin (BMG), connective tissue-cell outgrowths of neonatal rat muscle in tissue culture differentiate into cartilage. The muscle explant was suspended on a cellulose acetate membrane and separated from the BMG by a wire-grid platform and 2 ml of culture medium. Cartilage differentiated even when the BMG was removed from the system, within the first 24 hr of culture. Cultures transplanted on the seventh day into a muscle pouch in syngeneic recipients for an additional 14 days produced deposits of cartilage and woven bone.This publication has 2 references indexed in Scilit:
- Uptake of Protein by Mammalian Cells: An Underdeveloped AreaScience, 1968
- Bone: Formation by AutoinductionScience, 1965