TADALAFIL (CIALIS™) FOR MEN WITH ERECTILE DYSFUNCTION
- 1 May 2002
- journal article
- Published by Wiley in International Journal Of Clinical Practice
- Vol. 56 (4), 300-304
- https://doi.org/10.1111/j.1742-1241.2002.tb11260.x
Abstract
Tadalafil is an inhibitor of phosphodiesterase type 5, and is currently undergoing regulatory review in the US and in Europe. Its chemical structure is significantly different from sildenafil, and in vitro studies confirm significant potency for PDE5 inhibition, with little activity against most of the other isoforms of the enzyme including PDE6, which is the isoform of the enzyme found within the retina. The half-life of tadalafil is 17.5 hours and clinical studies suggest significant activity 24 hours post-dosing. As with sildenafil, efficacy depends upon a normal sexual stimulus, and the drug can taken be as required. Tadalafil is effective in the treatment of men with erectile dysfunction, and it appears to have a relatively mild side-effect profile, with no visual side-effects noted.Keywords
This publication has 10 references indexed in Scilit:
- On-demand IC351 (Cialis™) enhances erectile function in patients with erectile dysfunctionInternational Journal Of Impotence Research, 2001
- Double-blind, crossover comparison of 3 mg apomorphine SL with placebo and with 4 mg apomorphine SL in male erectile dysfunction.European Urology, 2001
- The role of nitric oxide in penile erectionExpert Opinion on Pharmacotherapy, 2001
- Epidemiology of erectile dysfunction: results of the ‘Cologne Male Survey’International Journal Of Impotence Research, 2000
- Erectile DysfunctionNew England Journal of Medicine, 2000
- SildenafilDrugs, 1999
- EFFECTS OF SILDENAFIL ON THE RELAXATION OF HUMAN CORPUS CAVERNOSUM TISSUE IN VITRO AND ON THE ACTIVITIES OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE ISOZYMESJournal of Urology, 1998
- Treatment of Men with Erectile Dysfunction with Transurethral AlprostadilNew England Journal of Medicine, 1997
- The Rationale for Prostaglandin E1 in Erectile Failure: A Survey of Worldwide ExperienceJournal of Urology, 1996
- Impotence and Its Medical and Psychosocial Correlates: Results of the Massachusetts Male Aging StudyJournal of Urology, 1994