Haemorrhagic Toxicosis in Rats Given Butylated Hydroxytoluene
- 1 July 1981
- journal article
- research article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 49 (1), 14-20
- https://doi.org/10.1111/j.1600-0773.1981.tb00864.x
Abstract
Vascular permeability, platelet function, blood coagulation and fibrinolytic activity were examined in Sprague-Dawley male rats given 1.20% butylated hydroxytoluene (BHT) in the diet for 1 wk. BHT significantly increased the leakage of Evans blue from blood into epididymus. BHT inhibited the ADP-induced platelet aggregation and decreased the platelet factor 3 availability. Plasma prothrombin, factors IX, X, VII and VIII were decreased in rats given BHT. Fibrinolytic activity was little influenced by BHT-feeding.Keywords
This publication has 31 references indexed in Scilit:
- Effects of four bisphenolic antioxidants on lipid contents of rat liverToxicology Letters, 1981
- Species differences in the haemorrhagic response to butylated hydroxytolueneFood and Cosmetics Toxicology, 1980
- The effect of food restriction for 4 weeks on common toxicity parameters in male ratsToxicology and Applied Pharmacology, 1979
- The relationship between hemorrhage induced by butylated hydroxytoluene and its antioxidant properties or structural characteristicsToxicology and Applied Pharmacology, 1978
- Effects of low levels of butylated hydroxytoluene on the prothrombin index of male ratsFood and Cosmetics Toxicology, 1978
- Dose-response study of hemorrhagic death by dietary butylated hydroxytoluene (BHT) in male ratsToxicology and Applied Pharmacology, 1978
- Influence of polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs) to serum protein components in ratsBulletin of Environmental Contamination and Toxicology, 1977
- The effects of food restriction on hematology, clinical chemistry and pathology in the albino ratToxicology and Applied Pharmacology, 1973
- Effects of butylated hydroxytoluene on the enzyme activity and ultrastructure of rat hepatocytesFood and Cosmetics Toxicology, 1970
- Liver response tests. III. Liver enlargement and stimulation of microsomal processing enzyme activityFood and Cosmetics Toxicology, 1965