Further Observations on the Inhibition of Tumor Growth by Corynebacterium parvum with Cyclophosphamide. III. Effect of C. parvum on Cyclophosphamide Metabolism2

Abstract

Results of investigations employing [¹⁴C]cyclophosphamide (CY) demonstrated that even though total plasma radioactivity was similar in female C3HeB/FeJ mice treated either with CY alone or Corynebacterium parvum and CY, the proportion of total activity due to non metabolized CY was greater when C. parvum was used. These findings indicated that the anti-tumor effect of C. parvum may not have been entirely due to its immunopotentiating properties but may also have been related to its effect on the metabolism of CY.