Determination of plasma (1 → 3)-β-d-glucan: A new diagnostic aid to deep mycosis
- 1 January 1992
- journal article
- case report
- Published by Oxford University Press (OUP) in Medical Mycology
- Vol. 30 (4), 275-280
- https://doi.org/10.1080/02681219280000361
Abstract
We present additional evidence that plasma from patients with deep-seated mycoses contains (1-->3)-beta-D-glucan. Digestion of such samples with endo-(1-->3)-beta-D-glucanase completely abolished the ability of the plasma to activate factor-G, a horseshoe crab coagulation enzyme that is extremely sensitive to this polysaccharide. Measurement of plasma (1-->3)-beta-D-glucan is a promising method for the diagnosis of deep-seated mycoses and for monitoring the response of these infections to antifungal therapy.Keywords
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