Well-Defined, Air-Stable (NHC)Pd(Allyl)Cl (NHC = N-Heterocyclic Carbene) Catalysts for the Arylation of Ketones
- 16 October 2002
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 4 (23), 4053-4056
- https://doi.org/10.1021/ol026745m
Abstract
A number of palladium-N-heterocyclic carbene (NHC) complexes were found to be active catalysts for the arylation of ketones. A large number of substrates, both aryl halides and ketones, are compatible with the reaction conditions. The ketone arylation reactions are achieved with low catalyst loading in short reaction times using aryl chlorides and triflates as reactive partners.Keywords
This publication has 13 references indexed in Scilit:
- X-Ray Structural Characterization of a Monoorganotin AcidAngewandte Chemie International Edition, 2002
- A Highly Efficient Catalyst for the Telomerization of 1,3-Dienes with Alcohols: First Synthesis of a Monocarbenepalladium(0)-Olefin ComplexAngewandte Chemie International Edition, 2002
- Palladium-catalyzed α-arylation of aldehydes with aryl bromidesTetrahedron Letters, 2002
- Stable CarbenesChemical Reviews, 1999
- General and Efficient Catalytic Amination of Aryl Chlorides Using a Palladium/Bulky Nucleophilic Carbene SystemOrganic Letters, 1999
- Simple, Highly Active Palladium Catalysts for Ketone and Malonate Arylation: Dissecting the Importance of Chelation and Steric HindranceJournal of the American Chemical Society, 1999
- Synthesis and Characterization of 14-Electron Cyclopentadienyl Chromium(II) Complexes Containing a Heterocyclic Carbene LigandOrganometallics, 1999
- Asymmetric Arylation of Ketone EnolatesJournal of the American Chemical Society, 1998
- Palladium‐Catalyzed Regioselective Mono‐ and Diarylation Reactions of 2‐Phenylphenols and Naphthols with Aryl HalidesAngewandte Chemie International Edition in English, 1997
- Alkoxides as nucleophiles in (.pi.-allyl)palladium chemistry. Synthetic and mechanistic studiesJournal of the American Chemical Society, 1983