Demonstration of Gamma Globulin in Vascular Lesions of Experimental Necrotizing Arteritis in the Rat.

Abstract

Summary Experimental necrotizing arteritis was produced in female Sprague-Dawley rats by administration of large doses of DOCA and NaCl after unilateral nephrectomy. Presence of RGG in damaged vessel walls was demonstrated by fluorescence antibody technic of Coons. Gamma globulin is deposited in smooth muscle of damaged small arteries, especially in early phases of vascular damage, suggesting that antibody may not be required for this process.