ALTERATIONS IN ACETYLCHOLINESTERASE ISOENZYME PATTERN OF HIPPOCAMPUS AFTER SEPTAL LESIONS IN RAT BRAIN

Abstract
The effect of septal lesions upon the AChE [acetylcholinesterase] (EC 3.1.1.7) isoenzymic pattern in the hippocampus of the rat brain was studied 1-3 mo. after surgery by polyacrylamide disc electrophoresis. Alterations in the isoenzymic pattern were found in the membrane-bound but not in the soluble fraction of the enzyme. Besides the 2 slowly migrating bands seen in the membrane-bound AChE fraction of the normal hippocampus, the fast-migrating isoenzyme also became visible.