Synthesis and antitrypanosomal evaluation of E-isomers of 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives. Structure–activity relationships.
- 1 March 2000
- journal article
- Published by Elsevier in European Journal of Medicinal Chemistry
- Vol. 35 (3), 343-350
- https://doi.org/10.1016/s0223-5234(00)00131-8
Abstract
No abstract availableKeywords
This publication has 26 references indexed in Scilit:
- Synthesis and anti-trypanosomal activity of novel 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivativesIl Farmaco, 1998
- Cyclic Voltammetry and Electron Paramagnetic Resonance Studies of Some Analogues of Nifurtimox.Spectroscopy Letters, 1998
- Phenothiazine Inhibitors of Trypanothione Reductase as Potential Antitrypanosomal and Antileishmanial DrugsJournal of Medicinal Chemistry, 1998
- Preparation of Enamines from the Condensation of Glycine Esters with Nitro-Heterocyclic AldehydesHETEROCYCLES, 1997
- Aromatic guanyl hydrazones: Synthesis, structural studies and in vitro activity against Trypanosoma cruziBioorganic & Medicinal Chemistry Letters, 1995
- The Structure of Trypanosoma cruzitrypanothione Reductase in the Oxidized and NADPH Reduced StateProteins-Structure Function and Bioinformatics, 1994
- "Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease.Proceedings of the National Academy of Sciences, 1988
- Genotoxicity studies with two antichagasic drugsMutation Research Letters, 1987
- Trypanothione: A Novel Bis(glutathionyl)spermidine Cofactor for Glutathione Reductase in TrypanosomatidsScience, 1985
- Present status of chemotheraphy and chemoprophylaxis of human trypanosomiasis in the Western HemispherePharmacology & Therapeutics, 1979