Studies on hypersensitivity. I. Delayed and Arthustype skin reactivity to protein conjugates in guinea pigs.

Abstract

A study has been made of the immunization of guinea pigs with proteins conjugated with picryl, acetyl and ethoxymethylene-phenyloxazolone groups. Immunization by means of complexes of these substances with anti-protein and anti-hapten antisera have also been studied. Antibody production, anaphylactic and Arthus-type sensitivity and delayed skin sensitivity to the conjugates, to the carrier proteins and to unrelated proteins carrying the same haptenic group have been investigated.