THE ACCELERATING EFFECT OF CALCIUM AND OTHER CATIONS ON THE CONVERSION OF FIBRINOGEN TO FIBRIN 1
- 1 February 1954
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 33 (2), 206-210
- https://doi.org/10.1172/jci102886
Abstract
When ionic strength was maintained constant, Ca, Sr, Ba, Mg, Mn and ammonium salts accelerated the conversion of fibrinogen to fibrin by thrombin. Mercuric, cupric, cobaltous, nickelous, and ferric chlorides accelerated the clotting of fibrinogen by thrombin in low concns. but caused precipitation, presumably of proteins, in higher concns. Studies with labelled Ca indicate that this acceleration of clotting is not accompanied by the formation of a firm bond between the Ca ions and the fibrin clot.Keywords
This publication has 9 references indexed in Scilit:
- STUDIES ON A PROTEOLYTIC ENZYME IN HUMAN PLASMAThe Journal of Experimental Medicine, 1952
- The Accelerating Effect of Calcium on the Fibrinogen-Fibrin TransformationScience, 1952
- The conversion of fibrinogen to fibrin. VII. Rigidity and stress relaxation of fibrin clots; effect of calciumArchives of Biochemistry and Biophysics, 1951
- A NEW METHOD FOR THE DETERMINATION OF FIBRINOGEN IN SMALL SAMPLES OF PLASMA1951
- Studies on the Rôle of Calcium in the Coagulation of BloodActa Medica Scandinavica, 1950
- On the Solubility of Fibrin ClotsScience, 1948
- FIBRINOGEN - WITH SPECIAL REFERENCE TO ITS PREPARATION AND CERTAIN PROPERTIES OF THE PRODUCT1947
- A STUDY ON THE CONVERSION OF FIBRINOGEN TO FIBRINAmerican Journal of Physiology-Legacy Content, 1944
- FACTORS WHICH INFLUENCE THE ACTIVITY OF PURIFIED THROMBINAmerican Journal of Physiology-Legacy Content, 1942