Incorporation of pairwise interactions into the Lifson‐Roig model for helix prediction
- 1 June 1995
- journal article
- research article
- Published by Wiley in Protein Science
- Vol. 4 (6), 1161-1166
- https://doi.org/10.1002/pro.5560040614
Abstract
The helix/coil equilibrium of a peptide in solution can be modulated by a variety of side‐chain interactions that are not incorporated into the standard statistical mechanical models for prediction of peptide helical content. In this report, we describe a recursive formulation of the Lifson‐Roig model that facilitates incorporation of specific pairwise side‐chain interactions as well as nonspecific individual side‐chain capping interactions. Application of this extended model to a series of host/guest peptides indicates that the apparent AG value for a pairwise apolar interaction is dependent upon the spacing and orientation but not the sequential location of the participating residues. The apparent AG values for such interactions are about 40% greater than the corresponding apparent ΔΔG values obtained from difference measurements.Keywords
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