Tumor Immunity: Tumor Suppression in vivo Initiated by Soluble Products of Specifically Stimulated Lymphocytes
- 14 May 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 172 (3984), 729-731
- https://doi.org/10.1126/science.172.3984.729
Abstract
Supernatant fluids of specifically stimulated lymphocyte cultures were purified. Fractions containing migration inhibition factor when injected intra-dermally into strain-2 guinea pigs produced a reaction similar in appearance to delayed cutaneous hypersensitivity. There was an accumulation of mononuclear cells at the injection sites and the growth of syngeneic tumor grafts at the sites was suppressed.Keywords
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