Biology of the p21-Activated Kinases
Top Cited Papers
- 1 June 2003
- journal article
- review article
- Published by Annual Reviews in Annual Review of Biochemistry
- Vol. 72 (1), 743-781
- https://doi.org/10.1146/annurev.biochem.72.121801.161742
Abstract
The p21-activated kinases (PAKs) 1-3 are serine/threonine protein kinases whose activity is stimulated by the binding of active Rac and Cdc42 GTPases. Our understanding of the regulation and biology of these important signaling proteins has increased tremendously since their discovery in the mid-1990s. PAKs 1-3 are activated by a variety of GTPase-dependent and -independent mechanisms. This complexity reflects the contributions of PAK function in many cellular signaling pathways and the need to carefully control PAK action in a highly localized manner. PAKs serve as important regulators of cytoskeletal dynamics and cell motility, transcription through MAP kinase cascades, death and survival signaling, and cell-cycle progression. Consequently, PAKs have also been implicated in a number of pathological conditions and in cell transformation. We propose here a key role for PAK action in coordinating the dynamics of the actin and microtubule cytoskeletons during directional motility of cells, as well as in other functions requiring cytoskeletal polarization.Keywords
This publication has 219 references indexed in Scilit:
- Phosphorylation of p85 βPIX, a Rac/Cdc42-specific Guanine Nucleotide Exchange Factor, via the Ras/ERK/PAK2 Pathway Is Required for Basic Fibroblast Growth Factor-induced Neurite OutgrowthJournal of Biological Chemistry, 2002
- PAK1 Kinase Is Required for CXCL1-Induced ChemotaxisBiochemistry, 2002
- NF-κB at the crossroads of life and deathNature Immunology, 2002
- Lysophosphatidic Acid Stimulates p21-Activated Kinase in Vascular Smooth Muscle CellsBiochemical and Biophysical Research Communications, 2002
- Regulation of the Cool/Pix ProteinsPublished by Elsevier ,2002
- βPix-enhanced p38 Activation by Cdc42/Rac/PAK/MKK3/6-mediated PathwayJournal of Biological Chemistry, 2001
- An Oncogenic Epidermal Growth Factor Receptor Signals via a p21-activated Kinase-Caldesmon-Myosin Phosphotyrosine ComplexPublished by Elsevier ,2000
- p21-Activated Kinase PAK Phosphorylates Desmin at Sites Different from Those for Rho-Associated KinaseBiochemical and Biophysical Research Communications, 2000
- Structure of the Complex of Cdc42Hs with a Peptide Derived from P-21 Activated Kinase,Biochemistry, 2000
- αPix Stimulates p21-activated Kinase Activity through Exchange Factor-dependent and -independent MechanismsJournal of Biological Chemistry, 1999