Premature ovarian failure in nobox-deficient mice is caused by defects in somatic cell invasion and germ cell cyst breakdown
- 3 March 2011
- journal article
- gonadal physiology-and-disease
- Published by Springer Nature in Journal of Assisted Reproduction and Genetics
- Vol. 28 (7), 583-589
- https://doi.org/10.1007/s10815-011-9553-5
Abstract
Purpose To understand the mechanism of premature ovarian failure (POF). Methods The ultrastructural (electron microscopy) analysis of primordial ovarian follicles in Nobox deficient mice. Results We studied, for the first time, the fate of oogonia in embryonic (prenatal) mouse ovaries and showed that the abolishment of the transition from germ cell cysts to primordial follicles in the ovaries of Nobox deficient mice is caused by defects in germ cell cyst breakdown, leading to the formation of syncytial follicles instead of primordial follicles. Conclusions These results indicate that POF syndrome in Nobox deficient mice results from the faulty signaling between somatic and germ line components during embryonic development. In addition, the extremely unusual and abnormal presence of adherens junctions between unseparated oocytes within syncytial follicles indicates that faulty communication between somatic and germ cells is involved in, or leads to, abnormalities in the cell adhesion program.Keywords
This publication has 23 references indexed in Scilit:
- Electron microscopy, immunostaining, cytoskeleton visualization, in situ hybridization, and three-dimensional reconstruction of Xenopus oocytesMethods, 2010
- β‐catenin–mediated signaling and cell adhesion in postgastrulation mouse embryosDevelopmental Dynamics, 2009
- Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin‐induced mouse follicular developmentMolecular Reproduction and Development, 2009
- Mutation analysis of NOBOX homeodomain in chinese women with premature ovarian failureFertility and Sterility, 2009
- Germ Cell-Specific Transcriptional Regulator Sohlh2 Is Essential for Early Mouse Folliculogenesis and Oocyte-Specific Gene Expression1Biology of Reproduction, 2008
- Mouse early oocytes are transiently polar: Three-dimensional and ultrastructural analysisExperimental Cell Research, 2008
- Genetic and Phenotypic Heterogeneity in Ovarian FailureAnnals of the New York Academy of Sciences, 2008
- Rab11 maintains connections between germline stem cells and niche cells in theDrosophilaovaryDevelopment, 2007
- NOBOX Homeobox Mutation Causes Premature Ovarian FailureAmerican Journal of Human Genetics, 2007
- cDNA cloning and expression of the human NOBOX gene in oocytes and ovarian folliclesMolecular Human Reproduction, 2006