Experimental Pyelonephritis in the Monkey. VII. Ascending Pyelonephritis in the Absence of vesicoureteral Reflux

Abstract

Adult male nonrefluxing monkeys [Cercopithecus aethiops] (6) were experimentally infected by inoculation of P-fimbriated Escherichia coli into the bladder. Eight control monkeys were inoculated with a non-P-fimbriated E. coli strain. Inoculation with the P-fimbriated E. coli resulted in marked leukocytosis, prolonged bacteriuria and loss of renal function with a 66% incidence of pyelonephritis. Death secondary to bilateral pyelonephritis was seen in 2 monkeys inoculated with P-fimbriated E. coli. Pyelonephritis was not seen in any of the monkeys inoculated with non-P-fimbriated E. coli. Ascending pyelonephritis can occur in monkeys in the absence of vesicoureteral reflux.