Immunoglobulin A1 in IgA Nephropathy

Abstract

To the Editor: We question whether IgA2 is a predominant subclass of IgA deposited in kidneys of patients with IgA nephropathy, as reported by André and his associates in the December 4 issue.¹ In contrast to their report, Conley et al. have found that IgA1 deposits selectively in IgA nephropathy.² One possible explanation for this contrast is that both groups of investigators used different sources of antiserum: André et al. used antiserums obtained from the Nordic Immunological Laboratories (Tilberg, The Netherlands), and Conley et al. used monoclonal hybridoma anti-IgA subclass antibodies.To test this hypothesis, we examined renal tissues of . . .