Studies on the Preparation and Nature of a Gastric Secretagogue of Pancreatic Origin

Abstract

MANY functional interrelations between stomach and pancreas are familiar and have been studied in many species. The endocrine secretion of insulin by beta cells of the islands of Langerhans is well established, with importance in the control of blood sugar levels and carbohydrate metabolism. Gastric hypermotility and hypersecretion are known to occur during hypoglycemia and may be induced by insulin administration. This appears to be mediated through the central nervous system by the vagus innervation of the stomach; the Hollander test to determine the assumed completeness of surgical vagotomy is based upon this relation. Data observed in human patients appear . . .