On the Relationship between the Activity of Acetylation, Growth of Experimental Tumors and Efficacy of their Suppression by Hydrazine Sulphate
- 1 January 1976
- journal article
- research article
- Published by S. Karger AG in Oncology
- Vol. 33 (5-6), 219-221
- https://doi.org/10.1159/000225149
Abstract
The growth of experimental tumors was found to involve an intensification of acetylation of sulphadimidine. Inhibition of carcinosarcoma Walker-256 by 88% and sarcoma-180 by 36% on treatment with 60 mg/kg body weight of hydrazine sulphate was followed by decreases in the rate of acetylation of 39.4 and 29.4%, respectively. When treatment failed to suppress tumor growth (sarcoma-45), acetylation level showed no decrease. The results point to a correlation between growth of tumors and their inhibition on the one hand and the level of acetylation on the other.Keywords
This publication has 6 references indexed in Scilit:
- ACETYLATION IN MICE EXPOSED TO THIOPHOSPHAMIDE AND HYDRAZINE SULFATE1976
- CORRELATION BETWEEN IMMUNE REACTIVITY AND FAT-CARBOHYDRATE METABOLISM - EFFECT OF PHENFORMIN1976
- ACETYLATION REACTION IN INTACT AND TUMOR-BEARING MICE1976
- Inhibition by Hydrazine of Gluconeogenesis in the RatJournal of Biological Chemistry, 1970
- Feedback Inhibition of Key Glycolytic Enzymes in Liver: Action of Free Fatty AcidsScience, 1966
- Inhibition of Acetyl Transfer by AmethopterinJournal of Biological Chemistry, 1960