Bactericidal activities of DU-6859a and clinafloxacin (CI-960) against staphylococci
Open Access
- 1 August 1994
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 38 (8), 1868-1870
- https://doi.org/10.1128/aac.38.8.1868
Abstract
Time killing curves were calculated at concentrations of 2 and 8 times the MICs of DU-6859a and clinafloxacin against six isolates of Staphylococcus aureus. Both quinolones produced a decrease in the log10 CFU per milliliter of > or = 3 within 3 h at 2 and 8 times the MIC for the ciprofloxacin-susceptible isolates and at 8 times the MIC for the ciprofloxacin-resistant isolates; however, only 8 times the MIC of DU-6859a consistently prevented regrowth of all isolates after 24 h of incubation.Keywords
This publication has 5 references indexed in Scilit:
- Antimicrobial activity of DU-6859, a new potent fluoroquinolone, against clinical isolatesAntimicrobial Agents and Chemotherapy, 1992
- CI-960, a new fluoroquinolone, for therapy of experimental ciprofloxacin-susceptible and -resistant Staphylococcus aureus endocarditisAntimicrobial Agents and Chemotherapy, 1992
- In vitro antistaphylococcal activities of two investigative fluoroquinolones, CI-960 and WIN 57273, compared with those of ciprofloxacin, mupirocin (pseudomonic acid), and peptide-class antimicrobial agentsAntimicrobial Agents and Chemotherapy, 1992
- Protective effect of amdinocillin against emergence of resistance to ceftazidime in Enterobacter cloacaeAntimicrobial Agents and Chemotherapy, 1988
- Effect of antibiotic carry-over on bacterial counting by ‘spiral plating’Journal of Antimicrobial Chemotherapy, 1988