The Parietal Cells in Duodenal Ulcer Patients
- 1 October 1980
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Gastroenterology
- Vol. 15 (7), 793-797
- https://doi.org/10.3109/00365528009181532
Abstract
Quantitative ultrastructural analyses of the parietal cells have been performed on eleven patients with chronic duodenal ulcer, before and after 8 weeks' treatment with a histamine H2-receptor antagonist (cimetidine, 1 g/day). The treatment caused a significant decrease of the secretory surface density; this result seems to differ from those of ultrastructural reports on parietal cells when acid secretion is inhibited by vagotomy. Furthermore, it was demonstrated that the profile of the tubulo-vesicles of parietal cells could be seen in three phases, tentatively suggesting that this system is able to take up material from the surrounding cytoplasm by encircling it.Keywords
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